Hi @LSdevon , I think much of the answer is about insulation. If you leave certain radiators off then are those rooms/spaces shut off. If so there might be gaps around the doors etc. 

Most people that I have spoken to leave their radiators on but reduce the flow temperature of the boiler. 
The Heat Geek guys are good at explaining things

You should also be able to set your hot water temperature separately which might be more economical 

Thanks for the link, I'll have a look at that! 

Great question, @LSdevon.

I’ve tweaked the title a bit to help others find it. Hopefully we’ll get some other tips here along with excellent advice from BPLightlog. 

Check out this topic about using infrared cameras to visually see poorly insulated areas of the home and what to do about them: